ACEMg Research Bibliography

Sillman JS, Larouere MJ, Nuttall AL, Lawrence M, Miller JM

Recent advances in cochlear blood flow measurements

Annals of Otology, Rhinology & Laryngology, 97(Suppl 135), 1-8 (1988)

Significance: Established foundation for understanding that changes in blood flow influence cochlear diseases, including noise-induced hearing loss.

Key Finding: Demonstrated measurable changes in cochlear circulation caused by various physiological factors.

Quirk WS, Wright JW, Dengerink JA, Miller JM

Angiotensin II-induced changes in cochlear blood flow and blood pressure in normotensive and spontaneously hypertensive rats

Hearing Research, 33(2), 129-136 (1988)

Significance: First demonstration of vasospasm's role in hearing pathology.

Miller JM, Ren T-Y, Nuttall AL

Studies of inner ear blood flow in animals and human beings

Otolaryngology - Head and Neck Surgery, 112(1), 101-113 (1995)

Significance: Comprehensive review of inner ear blood flow demonstrating autoregulatory capabilities significantly greater than brain autoregulation.

Key Finding: Established that decreased blood flow responsiveness occurs in hydropic ear conditions.

Yamasoba T, Nuttall AL, Harris C, Raphael Y, Miller JM

Role of glutathione in protection against noise-induced hearing loss

Brain Research, 784(1-2), 82-90 (1998)

Significance: First demonstration that endogenous antioxidant systems (glutathione) modulate noise-induced pathology.

Key Finding: GSH plays a critical protective role against noise-induced hearing loss (NIHL).

Yamasoba T, Harris C, Shoji F, Lee RJ, Nuttall AL, Miller JM

Influence of intense sound exposure on glutathione synthesis in the cochlea

Brain Research, 804(1), 72-78 (1998)

Significance: Demonstrated that noise exposure upregulates endogenous antioxidant systems.

Key Finding: Cochlear cells attempt to protect themselves by increasing GSH synthesis.

Ohinata Y, Miller JM, Altschuler RA, Schacht J

Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea

Brain Research, 878(1-2), 163-173 (2000)

Significance: Identified specific lipid peroxidation products formed during noise exposure.

Key Finding: Free radicals create vasoactive compounds that further damage the cochlea.

Shoji F, Miller AL, Mitchell A, Yamasoba T, Altschuler RA, Miller JM

Differential protective effects of neurotrophins in the attenuation of noise-induced hair cell loss

Hearing Research, 146(1-2), 134-142 (2000)

Significance: Demonstrated neurotrophins have antioxidant properties that reduce NIHL.

Shoji F, Yamasoba T, Magal E, Dolan DF, Altschuler RA, Miller JM

Glial cell line-derived neurotrophic factor has a dose-dependent influence on noise-induced hearing loss in the guinea pig cochlea

Hearing Research, 142(1-2), 41-55 (2000)

Significance: Established dose-response relationships for protective factors.

Ohinata Y, Miller JM, Schacht J

Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea

Brain Research, 966(2), 265-273 (2003)

Significance: Demonstrated that agents preventing free radical-induced lipid peroxidation also prevent NIHL.

Key Finding: Established the causal pathway from free radicals to lipid peroxidation to hair cell death.

Minami SB, Yamashita D, Schacht J, Miller JM

Calcineurin activation contributes to noise-induced hearing loss

Journal of Neuroscience Research, 78(3), 383-392 (2004)

Significance: Identified Calcineurin activation in NIHL pathway.

Takemura K, Komeda M, Yagi M, Himeno C, Izumikawa M, Doi T, Kuriyama H, Miller JM, Yamashita T

Direct inner ear infusion of dexamethasone attenuates noise-induced trauma in guinea pig

Hearing Research, 196(1-2), 58-68 (2004)

Significance: Demonstrated steroid treatment could attenuate NIHL.

Yamashita D, Jiang HY, Schacht J, Miller JM

Delayed production of free radicals following noise exposure

Brain Research, 1019(1-2), 201-209 (2004)

Significance: Found clinically significant late formation of free radicals 7-10 days post-noise, a critical discovery.

Key Finding: Treatment window extends well beyond the immediate post-exposure period.

Yamashita D, Miller JM, Jiang HY, Minami SB, Schacht J

AIF and EndoG in noise-induced hearing loss

Neuroreport, 15(18), 2719-2722 (2004)

Significance: Identified gene expression of abnormal proteins leading to cell death.

Yamashita D, Jiang HY, Le Prell CG, Schacht J, Miller JM

Post-exposure treatment attenuates noise-induced hearing loss

Neuroscience, 134(2), 633-642 (2005)

Significance: Demonstrated treatment can be effective even 3 days after noise exposure.

Key Finding: Opens therapeutic window for treatment after exposure has occurred.

Le Prell CG, Johnson AC, Lindblad AC, Skjonsberg A, Ulfendahl M, Guire K, Green GE, Campbell KCM, Miller JM

Increased vitamin plasma levels in Swedish military personnel treated with nutrients prior to automatic weapon training

Noise & Health, 13(55), 432-443 (2011)

Significance: First human safety and bioavailability study in the military population.

Key Finding: Nutrients are safely absorbed, and plasma levels are maintained during noise exposure.

Le Prell CG, Hensley BN, Campbell KC, Hall JW 3rd, Guire K

Evidence of hearing loss in a 'normally-hearing' college-student population

International Journal of Audiology, 50(Suppl 1), S21-S31 (2011)

Significance: Identified hidden hearing loss in young adults, establishing the need for preventive interventions.

Scheper V, Schmidtheisler M, Lasch F, von der Leyen H, Koch A, Schwieger J, Buchner A, Lesinski-Schiedat A, Lenarz T

Randomized placebo-controlled clinical trial investigating the effect of antioxidants and a vasodilator on overall safety and residual hearing preservation in cochlear implant patients

Trials, 21(1), 643 (2020)

Significance: First major randomized controlled trial of ACEMg in humans, demonstrated reduced hearing loss in ACEMg-treated patients compared to placebo-treated ones, suggesting that a perioperative oral administration of ACEMg is safe and may provide protection of residual hearing in cochlear implant patients.

Thatcher A, Le Prell C, Miller J, Green G

ACEMg supplementation ameliorates progressive Connexin 26 hearing loss in a child

International Journal of Pediatric Otorhinolaryngology, 78(3), 563-565 (2014)

Significance: First human case report. Three-year ACEMg regimen stopped progression and improved hearing in a child with Cx26 mutation.

Key Finding: Extended ACEMg application to genetic hearing loss.

Green KL, Swiderski DL, Prieskorn DM, DeRemer SJ, Beyer LA, Miller JM, Green GE, Raphael Y

ACEMg Diet Supplement Modifies Progression of Hereditary Deafness

Scientific Reports, 6, Article 22690 (2016)

Significance: ACEMg can influence genetic hearing loss progression.

Key Finding: Hearing thresholds measured by ABR were significantly better for Gjb2-CKO mice fed ACEMg than for the control diet group.